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The Israel’s Leading University Hospital stands as a beacon of leadership and excellence in the realm of healthcare, particularly in the fields of oncology, orphan diseases, bone marrow transplantation, genetic diagnostics, neurosurgery, cardiac surgery, cardiology, spinal surgery, pediatric plastic surgery and beyond. With a rich history dating back to its founding in 1918, this renowned institution has consistently pushed the boundaries of medical innovation and patient care.

What truly sets Israel’s Leading University Hospital apart is its unwavering commitment to innovation. The clinic actively collaborates with research institutions and embraces emerging technologies, ensuring that patients benefit from the latest breakthroughs in medical science. From telemedicine for remote consultations to robotic-assisted surgeries, Israel’s Leading University Hospital remains at the forefront of healthcare innovation.

Beyond its medical prowess, Israel’s Leading University Hospital fosters a culture of compassion and patient-centered care. The dedicated staff, from nurses to support personnel, consistently go above and beyond to ensure patients and their families feel supported and cared for.

To receive a consultation from one of the leading specialists of the Israel’s Leading University Hospital please contact our staff.

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The Sharet Oncology Institute at Israel’s Leading University Hospital University Clinic has become the only oncology center in Israel to be included in the prestigious ranking of the world’s best specialized oncology clinics by Newsweek magazine for the year 2022.

CAR-T therapy

Israel’s Leading University Hospital offers the world’s first outpatient CAR-T therapy. This therapy was developed at the Israel’s Leading University Hospital for the treatment of multiple myeloma, AL amyloidosis, and other malignant tumors that can be targeted through BCMA (B-cell maturation antigen).

The method involves altering the genes inside specific immune cells so that they can recognize and destroy cancer. Besides Israel, CAR-T therapy is only available in two other countries in the world (the USA and China).

According to Prof. Stepenski, this treatment can significantly prolong the lives of patients suffering from myeloma and greatly improve their quality of life.

Proton radiotherapy

In late June 2023, the first proton radiotherapy center in Israel was officially opened, the result of close collaboration between the Israel’s Leading University Hospital and P-Cure Ltd.

Now, Israeli patients suffering from head and neck cancer, recurrent brain cancer, or malignant tumors located near nervous centers no longer need to travel abroad, live there for extended periods, and spend vast sums of money (at the very least, $100,000 or more).

Proton therapy targets neoplasms that are resistant to conventional photon radiotherapy, has no side effects, and is much safer. Moreover, its cost in Israel will be significantly lower than in the United States.


Alpha DaRT is a type of brachytherapy known as Diffusing Alpha-emitters Radiation Therapy. This method was developed by the Israeli company Alpha Tau Medical in 2017, and in 2022, it began to be successfully applied at the Israel’s Leading University Hospital.

The essence of the method involves implanting microelements containing Radium-224 into the tumor, emitting alpha particles. Alpha radiation has several advantages compared to traditional photon radiation, one of the main ones being its excellent impact on neoplasms resistant to conventional radiotherapy.

ONCOSIL is a new form of brachytherapy, recently approved by the FDA (the U.S. Food and Drug Administration). This brachytherapy is designed for patients with locally advanced, inoperable pancreatic cancer in the late stages of development. In late May 2023, the ONCOSIL technology was first applied at Israel’s Leading University Hospital University Clinic. The procedure yielded excellent results.

Treatment of melanoma

Since 2002, Professor Michal Lotem’s vaccine has helped more than 200 patients suffering from stage 3 and 4 melanoma. The melanoma treatment is based on Adaptive Cell Therapy (ACT), using the patient’s own immune T-cells. Michal Lotem studied ACT under the renowned Professor Steven Rosenberg, the creator of the popular form of Adaptive Cell Therapy today known as the “TIL protocol.” Therefore, it is not surprising that both ACT and TIL are applied with exceptional effectiveness for melanoma treatment at the Israel’s Leading University Hospital today.

Surgical Oncology

Israel’s Leading University Hospital is known worldwide as a leader in the field of oncological surgery and intraoperative chemotherapy.

Infusion chemotherapy through the hepatic artery

The Israel’s Leading University Hospital is the first clinic outside the United States to use the Intera 3000 pump. Currently, it is the only such device approved by the U.S. Food and Drug Administration (FDA) for delivering chemotherapy to the liver through the hepatic artery. Chemotherapy with this pump is used in two main cases: when there are liver metastases due to colorectal cancer and when primary hepatocellular carcinoma develops. Clinical studies conducted over many years at the Memorial Sloan-Kettering Cancer Center in New York show that infusion chemotherapy through the hepatic artery doubles patient survival rates, significantly reduces the number of recurrences, and greatly increases the chances of complete recovery.

The procedure is performed by the experienced surgeon Dr. Muhammad Adileh.

Orphan diseases: BMT and genetic diagnostics

At Israel’s Leading University Hospital, BMT is used for orphan diseases in children, leukemias, lymphomas, and rapidly progressing scleroderma.

The bone marrow transplantation department at Israel’s Leading University Hospital is considered one of the leading departments in this field in Israel and abroad. Experts from around the world consult with Professor Stepensky, Head of the department, in the treatment of complex cases, and decisions made with her assistance have helped save patients’ lives.

In 2018, the Bone Marrow Transplantation Department at Israel’s Leading University Hospital became the first bone marrow transplantation center in Israel to receive accreditation from the International Society for Cell & Gene Therapy Europe & European Society for Blood and Marrow Transplantation (JACIE).

The international recognition of the department is well-deserved: by the beginning of 2023, the clinic had conducted approximately 4,500 bone marrow transplants, including 1,500 for children. The success rate of bone marrow transplantation here surpasses all current standards and stands at 95%.

Israel’s Leading University Hospital University Clinic is a recognized leader in the field of orphan disease research, with world-renowned scientists working here, such as Professor Orli Elpeleg, a leading geneticist, pediatrician, and head of the Department of Genetic and Metabolic Diseases.

Often, Israel’s Leading University Hospital hosts leading foreign scientists, and Professor Elpeleg leads one of such international research groups. The laboratories and research institutes at Israel’s Leading University Hospital are constantly engaged in the discovery of previously unknown rare diseases, as well as the development and implementation of new diagnostic and treatment methods.

In 2012, Professor Orli Elpeleg, the head of the Genetics Department at Israel’s Leading University Hospital, became the first specialist in Israel to initiate exome sequencing research.

The genetics department, under the leadership of Professor Elpeleg, achieved tremendous success. They discovered over 100 new gene mutations that cause various serious diseases.


The Israel’s Leading University Hospital excels in the treatment of aneurysms, stenosis, congenital deformities, and many other vascular pathologies of the head and neck.

Israel’s Leading University Hospital is the only medical institution in the Middle East where patients over the age of 80 are treated for strokes. In January 2018, a similar operation was performed on a 99-year-old patient.

In 2018, the neurosurgeons at Israel’s Leading University Hospital became the first in Israel to use the unique and most powerful surgical microscope to date, the KINEVO 900, created by the renowned German company Zeiss. This device elevates neurosurgery to a new level: its robotic system optimally controls lighting and viewing angles, the endoscopic instrument allows access to previously unreachable areas, and blood flow visualization ensures that the doctor does not disrupt it with their actions.

Israel’s Leading University Hospital is the only medical institution in the world to use a protocol that allows patients to undergo a CT or MRI scan and begin treatment within just 30 minutes from the moment of admission to the department.

The neurosurgeons at Israel’s Leading University Hospital treat newborns from the moment of their birth and elderly individuals of almost any age. The age of 99 has been a current record, but according to Prof. Jose Cohen, even 100 years is not the limit.

In 2022 doctors at the Israel’s Leading University Hospital performed a rare procedure just 2 hours after the birth of a baby through the umbilical cord, which was intentionally left uncut to create a channel for brain catheterization.

The procedure was carried out by the world-renowned neurosurgeon and head of the brain catheterization department at the Israel’s Leading University Hospital, Prof. Jose Cohen. Catheterization became necessary after the detection of a rare malformation of the Galen vein in the fetus during a routine check-up. This malformation can lead to dangerous cardiac or renal insufficiency, liver dysfunction, and brain disorders.

Spinal Surgery

Israel’s Leading University Hospital is a global leader in the application of robotic systems and artificial intelligence in the field of spinal surgery.

The Israeli startup Pathkeeper has received approval from the FDA (the U.S. Food and Drug Administration) for the use of a unique, non-radiation-based navigation system for spinal surgeries.

This system allows for real-time tracking of the position of surgical instruments in relation to the spine and nerves. Images are captured using a 3D camera, and artificial intelligence analyzes these images by comparing them to preoperative CT scans.

The innovative system was created by Erez Lampert, the director and founder of Pathkeeper, a specialist in 3D medical visualization, and Dr. Josh Shreder, the head of the spinal surgery department at Israel’s Leading University Hospital.

In 2021, Israel’s Leading University Hospital acquired a unique robotic system called “Mazor X Stealth Edition” from the company “Medtronic,” which is based on developments by Israeli specialists. This acquisition enabled the clinic’s orthopedic surgeons to successfully perform a highly complex spinal surgery, saving a 70-year-old patient from paralysis.


The prestigious American magazine Newsweek featured the cardiology department of Israel’s Leading University Hospital in its recently released special edition titled “Best Specialized Clinics in the World – Cardiology 2021.

Israel’s Leading University Hospital performs unique surgeries that are not available at other medical centers in Israel. For example, in 2021, they conducted the world’s first surgery that involved the simultaneous treatment of arrhythmia through ablation and the correction of the mitral valve. In the same year, cardiologists at the clinic performed the world’s first mitral valve replacement and stent placement to correct an aortic aneurysm in a single procedure.

In early 2021, for the first time in Israel, Israel’s Leading University Hospital began performing ablation of hard-to-reach atrial areas through the chest, offering hope for recovery to patients with arrhythmia who had no suitable treatment options before.

In March 2019, Israel’s Leading University Hospital became the only clinic in Israel where mitral valve correction is performed using third-generation MitraClip technology.

Pediatric plastic surgery: giant nevi

At Israel’s Leading University Hospital, hundreds of children with giant nevi have been helped, including those whom other clinics hesitated to treat.

The treatment of nevi in children in Israel at Israel’s Leading University Hospital is carried out using state-of-the-art equipment. There are few clinics in the country equipped at the same level, which allows doctors to maximize their potential and achieve the most impressive results in the country.

Among the latest means of removing large birthmarks widely used by plastic surgeons at the clinic, special computer monitoring systems for birthmarks, especially large ones, and laser technologies should be mentioned.


The Department of In Vitro Fertilization (IVF) at Israel’s Leading University Hospital University Clinic has been operating since 1982 and has been a leader in Israel in the field of IVF and related procedures throughout this time. Israel’s Leading University Hospital is home to the national sperm donor bank in Israel.

Infertility treatment in Israel is centered around IVF. The doctors in the department specialize not only in treating challenging cases of infertility but also in successfully performing IVF for women with chronic and severe illnesses that would seemingly preclude pregnancy. For example, many patients with artificial hearts, genetic blood disorders, various oncological diseases who have undergone extensive radiation and chemotherapy have successfully given birth to healthy children here. Only at Israel’s Leading University Hospital do reproductive specialists and infectious disease experts assist couples in which one partner is a carrier of HIV or AIDS in giving birth to a child without immunodeficiency.

Ocular Oncology

The center was founded and is led by the world-renowned specialist Professor Yaakov Peer, who in 2021 became the first in Israel to receive the prestigious award from the Association for Research in Vision and Ophthalmology (ARVO), and in 2018 received the “Fighting Blindness” award from the American Academy of Ophthalmology.

The Center completely cures 95-98% of patients with eye cancer, preserving the affected organ of vision in 70% of cases.

The innovative Optical Coherence Tomography (OCT) LIVE system, which uses harmless light waves for eye examination, allows for much more precise and safe tumor removal surgery.

The combination of intra-arterial chemotherapy and direct chemotherapy administration are innovative methods that oncology ophthalmologists at Israel’s Leading University Hospital were the first in Israel to use in the treatment of retinoblastoma. Over the past years, these methods have saved the eyes of more than 100 patients.

To receive a consultation from one of the leading specialists of the Israel’s Leading University Hospital please contact our staff.




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